Comprehensive analysis of HOX family genes in endometrial cancer.

ABSTRACT:

Background

Endometrial cancer (EC) is one of the most prevalent malignancies in the female population. Homeoboxes (HOXs) are a large family of transcription factors that have a variety of functions in biological processes (BPs), including developmental differentiation, and their dysregulated expression has been implicated in tumorigenesis. However, the involvement of HOXs in EC has received little attention. Thus, we aimed to identify the potential role of HOXs in EC from a multi-omics perspective through bioinformatics analysis.

Methods

We obtained transcriptome, mutation, and methylation data and the corresponding clinical data for normal and tumor tissues from The Cancer Genome Atlas (TCGA) database. Abnormal expression of HOXs in EC was identified via differential analys

SUBMITTER: Zhao L 

PROVIDER: S-EPMC10774039 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature