Identification of the function of FOSB in cholangiocarcinoma using bioinformatics analysis.

ABSTRACT:

Background

Exploring the potential mechanism of cholangiocarcinoma (CCA) metabolic reprogramming is significant for guiding clinical treatment. However, related research and exploration are still lacking. Therefore, we aimed to identify a reliable metabolism-related gene or biomarker of CCA using bioinformatics analysis.

Methods

The GSE26566, GSE45001, and GSE132305 datasets were obtained from the Gene Expression Omnibus (GEO) database. Differently expressed genes (DEGs) between CCA tissues and adjacent tissues were screened out. The key gene was identified through enrichment and functional analysis, and its immune and clinical correlation was investigated utilizing the Tumor Immune Evaluation Resource (TIMER2.0), the Tumor-Immune System Interactions Database (TISIDB), the G

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10774044 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature