A novel prognostic and therapeutic target biomarker based on complement-related gene signature in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most prevalent cancer types that reduce human life expectancy. The current tumor-node-metastasis (TNM) staging system is inadequate in identifying higher or lower risk of GC patients because of tumor heterogeneity. Research shows that complement plays a dual role in the tumor development and progression of GC.

Methods

We downloaded GC data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). A complement-related risk signature was constructed through bioinformatics analysis. Subsequently, the predictive ability of this signature was validated with GSE84437 dataset, and a nomogram integrating risk score and common clinical factors was established. Besides, we evaluated the association of risk score with the immune

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10774048 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature