Establishment and validation of a prognostic immune-related lncRNA risk model for acute myeloid leukemia.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a cancer arising in the bone marrow and is the most common type of adult leukemia. AML has a poor prognosis, and currently, its prognosis evaluation does not include immune status assessment. This study established an immune-related long non-coding RNA (lncRNA) prognostic risk model for AML based on immune lncRNAs screening.

Methods

To construct training and validation cohorts, The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) public databases were accessed to obtain gene expression profiles and clinical data. The correlation between lncRNAs and immunity genes was analyzed using the "limma" package, and the immune-related lncRNAs were obtained. Through least absolute shrinkage and selection operator regression, a prog

SUBMITTER: Xie KY 

PROVIDER: S-EPMC10774049 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature