A model for predicting clinical prognosis based on brain metastasis-related genes in patients with breast cancer.

ABSTRACT:

Background

Brain metastasis (BM) is a clinically relevant cause of death in patients with breast cancer (BRCA). This study was designed to develop a clinical model capable of predicting BRCA patients' prognostic outcomes according to the expression of BM-related genes (BMRGs).

Methods

The public Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases served as data sources. BMRGs of BRCA were selected from previous literature. Differences among BRCA molecular subtypes were compared using R 'limma' package. The impact of BM-related differentially expressed genes (BM_DEGs) on BRCA patients' outcomes was explored with a risk score model, after which the relationship between these risk scores and immune cell infiltration was examined. Risk scores were also use

SUBMITTER: Yuan J 

PROVIDER: S-EPMC10774057 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature