[Associations of circulating leptin levels with colorectal adenoma and colorectal cancer: a case-control and Mendelian randomization study].

ABSTRACT:

Objective

To explore the causal association between circulating leptin levels and the risk of colorectal adenoma and colorectal cancer.

Methods

We collected demographic and clinical data and serum samples from 497 patients with colorectal adenoma, 955 patients with colorectal cancer, and 911 healthy individuals from the First Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang Cancer Hospital, Zhuji People's Hospital, and Lin'an District First People's Hospital. Instrumental variables of leptin were selected and genotyping tests were performed. A logistic regression model and stratified analysis were used to evaluate the association of serum leptin levels with colorectal adenoma, colorectal cancer, and the progression of colorectal adenoma to colorectal c

SUBMITTER: Zhao H 

PROVIDER: S-EPMC10774100 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature