[Expression of interleukin-34 in tongue squamous cell carcinoma and its clinical implications].

ABSTRACT:

Objective

To investigate the expression of interleukin- 34 (IL-34) in tongue squamous cell carcinoma (TSCC) and its clinical implications.

Methods

Serum IL-34 level was detected in 36 patients with TSCC and 36 healthy individuals using enzymelinked immunosorbent assay (ELISA). The expressions of IL-34 mRNA and protein levels in TSCC and adjacent tissues were examined in 41 patients using real-time fluorescence quantitative PCR (qRT-PCR) and immunohistochemistry (IHC), and their correlation with the clinicopathological features of the patients was further analyzed. Informatic analysis of the differentially expressed genes related with IL-34 in TSCC was carried out based on String database, LinkedOmics database and GEO database, and GO functional analysis and KEGG signaling pa

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10774107 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature