Integrating TSPO PET imaging and transcriptomics to unveil the role of neuroinflammation and amyloid-β deposition in Alzheimer's disease.

ABSTRACT:

Purpose

Despite the revealed role of immunological dysfunctions in the development and progression of Alzheimer's disease (AD) through animal and postmortem investigations, direct evidence regarding the impact of genetic factors on microglia response and amyloid-β (Aβ) deposition in AD individuals is lacking. This study aims to elucidate this mechanism by integrating transcriptomics and TSPO, Aβ PET imaging in clinical AD cohort.

Methods

We analyzed 85 patients with PET/MR imaging for microglial activation (TSPO, [¹⁸F]DPA-714) and Aβ ([¹⁸F]AV-45) within the prospective Alzheimer's Disease Immunization and Microbiota Initiative Study Cohort (ADIMIC). Immune-related differentially expressed genes (IREDGs), identified based on AlzData, were screened and ve

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10774172 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature