The prognostic significance of a negative PSMA-PET scan prior to salvage radiotherapy following radical prostatectomy.

ABSTRACT:

Aim

The optimal management for early recurrent prostate cancer following radical prostatectomy (RP) in patients with negative prostate-specific membrane antigen positron-emission tomography (PSMA-PET) scan is an ongoing subject of debate. The aim of this study was to evaluate the outcome of salvage radiotherapy (SRT) in patients with biochemical recurrence with negative PSMA PET finding.

Methods

This retrospective, multicenter (11 centers, 5 countries) analysis included patients who underwent SRT following biochemical recurrence (BR) of PC after RP without evidence of disease on PSMA-PET staging. Biochemical recurrence-free survival (bRFS), metastatic-free survival (MFS) and overall survival (OS) were assessed using Kaplan-Meier method. Multivariable Cox proportional hazards

SUBMITTER: Adebahr S 

PROVIDER: S-EPMC10774185 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature