Hormonal Therapies in Multiple Sclerosis: a Review of Clinical Data.

ABSTRACT:

Purpose of review

Given the potential for exogenous hormones to influence risk and course of MS, this narrative review aims to summarize current knowledge from observational and interventional studies of exogenous hormones in humans with MS.

Recent findings

Large randomized clinical trials for combined oral contraceptives and estriol both show modest effect on inflammatory activity, with the latter showing potential neuroprotective effect. After fertility treatment, large actively treated cohorts have not confirmed any elevated risk of relapse. Preclinical data suggest that androgens, selective estrogen receptor modulators (SERMs), and selective androgen receptor modulators (SARMs) may be neuroprotective but clinical data are lacking. Gender affirming treatment, particularly

SUBMITTER: Hsu S 

PROVIDER: S-EPMC10774191 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature