Identification of gene expression biomarkers to predict clinical response to methotrexate in patients with rheumatoid arthritis.

ABSTRACT:

Objectives

To identify biomarkers at the gene expression level to predict response to methotrexate (MTX) in patients with rheumatoid arthritis (RA).

Methods

MTX-naïve patients with RA were started on MTX and followed up over three months. The disease activity score 28 (DAS28) was used to classify patients into responders and non-responders. Genome-wide gene expression analysis was performed in CD4 + and CD14 + mononuclear cells sampled from whole blood at baseline to identify differentially expressed genes in responders versus non-responders. Gene selection methods and prediction modelling obtained the most relevant differentially expressed genes. A logistic regression prediction model was subsequently constructed and validated via bootstrapping. The area under the receiver

SUBMITTER: Palmowski A 

PROVIDER: S-EPMC10774206 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature