Diagnostic accuracy of anti-3-[¹⁸F]-FACBC PET/MRI in gliomas.

ABSTRACT:

Purpose

The primary aim was to evaluate whether anti-3-[¹⁸F]FACBC PET combined with conventional MRI correlated better with histomolecular diagnosis (reference standard) than MRI alone in glioma diagnostics. The ability of anti-3-[¹⁸F]FACBC to differentiate between molecular and histopathological entities in gliomas was also evaluated.

Methods

In this prospective study, patients with suspected primary or recurrent gliomas were recruited from two sites in Norway and examined with PET/MRI prior to surgery. Anti-3-[¹⁸F]FACBC uptake (TBR_peak) was compared to histomolecular features in 36 patients. PET results were then added to clinical MRI readings (performed by two neuroradiologists, blinded for histomolecular results and PET data) t

SUBMITTER: Karlberg A 

PROVIDER: S-EPMC10774221 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature