Causal associations between gut microbiota and regional cortical structure: a Mendelian randomization study.

ABSTRACT:

Introduction

Observational studies have reported associations between gut microbiota composition and central nervous system diseases. However, the potential causal relationships and underlying mechanisms remain unclear. Here, we applied Mendelian randomization (MR) to investigate the causal effects of gut microbiota on cortical surface area (SA) and thickness (TH) in the brain.

Methods

We used genome-wide association study summary statistics of gut microbiota abundance in 18,340 individuals from the MiBioGen Consortium to identify genetic instruments for 196 gut microbial taxa. We then analyzed data from 56,761 individuals from the ENIGMA Consortium to examine associations of genetically predicted gut microbiota with alterations in cortical SA and TH globally and across 34 f

SUBMITTER: Zhou M 

PROVIDER: S-EPMC10774226 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature