Proliferation and apoptosis after whole-body irradiation: longitudinal PET study in a mouse model.

ABSTRACT:

Purpose

A reliable method for regional in vivo imaging of radiation-induced cellular damage would be of great importance for the detection of therapy-induced injury to healthy tissue and the choice of adequate treatment of radiation emergency patients in both civilian and military events. This study aimed to investigate in a mouse model if positron emission tomography (PET) imaging with proliferation and apoptosis markers is potentially suitable for this purpose.

Methods

Four groups, including twenty mice (wild-type C57BL/6) each, were whole-body irradiated with 0 Gy, 0.5 Gy, 1 Gy, and 3 Gy and examined by PET over a six-month period at defined time points. 3'-[¹⁸F]fluoro-3'-deoxythymidine ([¹⁸F]FLT) and 2-(5-[¹⁸F]fluoropentyl)-2-methyl malon

SUBMITTER: Meindl M 

PROVIDER: S-EPMC10774227 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature