Radiation-induced changes in energy metabolism result in mitochondrial dysfunction in salivary glands.

ABSTRACT: Salivary glands are indirectly damaged during radiotherapy for head and neck cancer, resulting in acute and chronic hyposalivation. Current treatments for radiation-induced hyposalivation do not permanently restore function to the gland; therefore, more mechanistic understanding of the damage response is needed to identify therapeutic targets for lasting restoration. Energy metabolism reprogramming has been observed in cancer and wound healing models to provide necessary fuel for cell proliferation; however, there is limited understanding of alterations in energy metabolism reprogramming in tissues that fail to heal. We measured extracellular acidification and oxygen consumption rates, assessed mitochondrial DNA copy number, and tested fuel dependency of irradiated primary salivary acinar

SUBMITTER: Buss LG 

PROVIDER: S-EPMC10774336 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature