MiR-195b is required for proper cellular homeostasis in the elderly.

ABSTRACT: Over the last decade we have witnessed an increasing number of studies revealing the functional role of non-coding RNAs in a multitude of biological processes, including cellular homeostasis, proliferation and differentiation. Impaired expression of non-coding RNAs can cause distinct pathological conditions, including herein those affecting the gastrointestinal and cardiorespiratory systems, respectively. miR-15/miR-16/miR-195 family members have been broadly implicated in multiple biological processes, including regulation of cell proliferation, apoptosis and metabolism within distinct tissues, such as heart, liver and lungs. While the functional contribution of miR-195a has been reported in multiple biological contexts, the role of miR-195b remains unexplored. In this study we dissected

SUBMITTER: Munoz-Gallardo MDM 

PROVIDER: S-EPMC10774362 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature