Effects of Black Raspberry Supplementation on Methylation Pathways in Vav-creAsxl1^fl/flTet2^fl/fl Double Knockout Mice with Early-stage Myelodysplastic Syndrome.

ABSTRACT: Myelodysplastic syndromes (MDS) are a subset of myeloid malignancies defined by clonality of immature hematopoietic stem cells that leads to faulty blood cell development. These syndromes can lead to an increased risk of infection and may transform into acute myeloid leukemia, making it critical to determine effective treatments for the condition. While hypomethylating agents such as azacitidine and decitabine, as well as stem cell transplants, have been delineated as favored treatments for MDS, not all patients are physiologically receptive to these treatments. However, black raspberries (BRBs) have been shown to exert hypomethylating effects in various malignancies, with minimal adverse effects and thus a broader range of potential candidacies. This study aimed to investigate the potenti

SUBMITTER: Dong A 

PROVIDER: S-EPMC10774484 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature