Long-axial field-of-view PET/CT for the assessment of inflammation in calcified coronary artery plaques with [⁶⁸ Ga]Ga-DOTA-TOC.

ABSTRACT:

Purpose

Inflamed, prone-to-rupture coronary plaques are an important cause of myocardial infarction and their early identification is crucial. Atherosclerotic plaques are characterized by overexpression of the type-2 somatostatin receptor (SST₂) in activated macrophages. SST₂ ligand imaging (e.g. with [⁶⁸ Ga]Ga-DOTA-TOC) has shown promise in detecting and quantifying the inflammatory activity within atherosclerotic plaques. However, the sensitivity of standard axial field of view (SAFOV) PET scanners may be suboptimal for imaging coronary arteries. Long-axial field of view (LAFOV) PET/CT scanners may help overcome this limitation. We aim to assess the ability of [⁶⁸ Ga]Ga-DOTA-TOC LAFOV-PET/CT in detecting calcified, SST₂ overe

SUBMITTER: Mingels C 

PROVIDER: S-EPMC10774639 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature