Prognostic implications of invasive hemodynamics during cardiac resynchronization therapy: Stroke work outperforms dP/dt_max.

ABSTRACT:

Background

Invasive measurements of left ventricular (LV) hemodynamic performance can evaluate acute response to cardiac resynchronization therapy (CRT).

Objective

The study sought to determine which metric, maximum rate of LV pressure rise (LV dP/dt_max) or LV stroke work (LVSW), is more strongly associated with long-term prognosis.

Methods

CRT patients were prospectively included from 3 academic centers. Invasive pressure-volume loop measurements during implantation were performed, and LV dP/dt_max and LVSW were determined at baseline and during biventricular pacing (BVP) as well as their relative increase (%Δ). Hazard ratios (HRs) for the primary outcome of 8-year all-cause mortality were derived using Cox proportional hazards. The secondary end

SUBMITTER: Wouters PC 

PROVIDER: S-EPMC10774665 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature