Severe vs Nonsevere Immune Checkpoint Inhibitor-Induced Myocarditis: Contemporary 1-Year Outcomes.

ABSTRACT:

Background

The long-term contemporary outcomes of patients with immune checkpoint inhibitor (ICI) myocarditis, spanning the spectrum of clinical severity, are undetermined.

Objectives

We sought to investigate the characteristics and cardiovascular outcomes of patients with severe and nonsevere ICI myocarditis.

Methods

This was a retrospective cohort study of patients with suspected ICI myocarditis at Massachusetts General Brigham Health System conducted between 2015 and 2022. Cases were classified as severe, nonsevere, and negative based on the International Cardio-Oncology Society criteria. One-year cardiovascular mortality, all-cause mortality, and cardiovascular readmissions were evaluated. We also evaluated 1-year ICI resumption and left ventricular ejection fract

SUBMITTER: Itzhaki Ben Zadok O 

PROVIDER: S-EPMC10774775 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature