Regulatory T cells Are Increased and Correlate With Mast Cells in Eosinophilic Esophagitis.

ABSTRACT:

Background/aims

The incidence of eosinophilic esophagitis (EoE) has been increasing recently. The role of regulatory T cells (Tregs) and correlations with other inflammatory cells in EoE remain unknown. We aim to clarify the role of Tregs and their correlations with inflammatory cells in EoE patients.

Methods

Biopsies from controls and EoE patients before and after treatments were analyzed. Eosinophil infiltration was evaluated by hematoxylin and eosin staining. Immunohistochemical staining was performed to examine infiltration of T cells, Tregs, and mast cells. Gene expressions of chemokines were evaluated by reverse transcription-quantitative polymerase chain reaction.

Results

Tregs and mast cells were increased in the esophageal epithelial layers of EoE patients. A

SUBMITTER: Chen J 

PROVIDER: S-EPMC10774801 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature