Synthesis of novel fluorescence probes and their application in the enantioselective recognition of arginine.

ABSTRACT: Arginine (Arg) plays a crucial and multifaceted role in various biological processes, encompassing cell division, wound healing, immune system modulation, and plant signaling. This study introduced a pair of novel chiral fluorescent probes, (R)-5 and (S)-5, constructed upon the BINOL framework, which exhibited enantiomeric selectivity and sensitivity to d-Arg/l-Arg in fluorescence experiments. These probes offered a simple, rapid, low-cost, and highly selective method for detecting Arg enantiomers, thereby providing a highly sensitive approach for their qualitative and quantitative analysis. The enantioselective fluorescence enhancement ratios {ef = [(I1 - I0)/(I2 - I0) = ΔI1/ΔI2]} of (R)-5 and (S)-5 to Arg were 1694 and 5163, respectively. Moreover, the probes demonstrated the capability

SUBMITTER: Xu J 

PROVIDER: S-EPMC10774859 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature