Conventional follicular-phase ovarian stimulation vs. luteal-phase stimulation in suboptimal responders: a randomized controlled trial.

ABSTRACT:

Objective

To compare the oocyte yield between follicular-phase stimulation (FPS) and luteal-phase stimulation (LPS) in suboptimal responders.

Design

Prospective, randomized, crossover clinical trial.

Patients

Forty-one patients with infertility according to the POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) criteria (1b/2b).

Interventions

Crossover study on 2 assigned ovarian stimulations that started randomly in the follicular or luteal phase. The in vitro fertilization cycles were not consecutive but separated in time (45 days to 6 months). The random crossover design ensured that all subjects received the first treatment by chance.

Main outcome measures

The primary objective was the number of cumulus-oocyte complexes

SUBMITTER: Sunol J 

PROVIDER: S-EPMC10774905 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature