Clinical relevance of gene mutations and rearrangements in advanced differentiated thyroid cancer.

ABSTRACT:

Background

Tumor genotyping is becoming crucial to optimize the clinical management of patients with advanced differentiated thyroid cancer (DTC); however, its implementation in clinical practice remains undefined. We herein report our single-center experience on molecular advanced DTC testing by next-generation sequencing approach, to better define how and when tumor genotyping can assist clinical decision making.

Materials and methods

We retrospectively collected data on all adult patients with advanced DTC who received molecular profiling at the IRCSS Sant'Orsola-Malpighi Hospital from 2008 to 2022. The genetic alterations were correlated with radioactive iodide refractory (RAI-R), RAI uptake/disease status, and time to RAI resistance (TTRR) development.

Results

A

SUBMITTER: Nannini M 

PROVIDER: S-EPMC10774965 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature