Sibling Death in Childhood and Early Adulthood and Risk of Early-Onset Cardiovascular Disease.

ABSTRACT:

Importance

Sibling death is a highly traumatic event, but empirical evidence on the association of sibling death in childhood and early adulthood with subsequent risk of incident cardiovascular disease (CVD) remains limited.

Objective

To evaluate the association between sibling death in the early decades of life and subsequent risk of incident early-onset CVD.

Design, setting, and participants

This population-based cohort study included 2 098 659 individuals born in Denmark from 1978 to 2018. Follow-up started at age 1 year or the date of the first sibling's birth, whichever occurred later, and it ended at the first diagnosis of CVD, the date of death, emigration, or December 31, 2018, whichever came first. Data analyses were conducted from November 1, 2021, through J

SUBMITTER: Huang C 

PROVIDER: S-EPMC10774991 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature