Cathepsin detection to identify malignant cells during robotic pulmonary resection.

ABSTRACT:

Background

Intraoperative molecular imaging (IMI) uses a fluorescent probe to identify occult cancers. VGT-309 is a quenched activity-based probe that is activated in the presence of cathepsins, enzymes overexpressed in cancer cells, and detected by near-infrared (NIR) light. This study aims to evaluate the sensitivity and the positive predictive value (PPV) of robotic-assisted thoracic surgery (RATS) with intraoperative molecular imaging (RIMI) using VGT-309 to localize tumors using NIR light to detect areas with increased cathepsin activity. Our secondary outcome was to compare RIMI to video-assisted thoracic surgery (VATS) with intraoperative molecular imaging (VIMI).

Methods

In a phase 2 clinical trial at the University of Pennsylvania, patients (n=10) with suspicious pu

SUBMITTER: Bou-Samra P 

PROVIDER: S-EPMC10775009 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature