Markers of epidemiological success of methicillin-resistant Staphylococcus aureus isolates in European populations.

ABSTRACT:

Objectives

Methicillin-resistant Staphylococcus aureus (MRSA) infections impose a considerable burden on health systems, yet there is remarkable variation in the global incidence and epidemiology of MRSA. The MACOTRA consortium aimed to identify bacterial markers of epidemic success of MRSA isolates in Europe using a representative MRSA collection originating from France, the Netherlands and the United Kingdom.

Methods

Operational definitions of success were defined in consortium meetings to compose a balanced strain collection of successful and sporadic MRSA isolates. Isolates were subjected to antimicrobial susceptibility testing and whole-genome sequencing; genes were identified and phylogenetic trees constructed. Markers of epidemiological success were identified using g

SUBMITTER: Baede VO 

PROVIDER: S-EPMC10775016 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature