CD47 overexpression is related to tumour-associated macrophage infiltration and diffuse large B-cell lymphoma progression.
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ABSTRACT:
SUBMITTER: Shen YG
PROVIDER: S-EPMC10775178 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
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CD47 overexpression is related to tumour-associated macrophage infiltration and diffuse large B-cell lymphoma progression.
Shen Yi-Ge YG Ji Meng-Meng MM Yi Hong-Mei HM Shen Rong R Fu Di D Cheng Shu S Huang Chuan-Xin CX Wang Li L Xu Peng-Peng PP Dou Hong-Jing HJ Zhao Wei-Li WL
Clinical and translational medicine 20240101 1
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Project description:At present, the use of the common chemotherapy regimen CHOP/R-CHOP for diffuse large B-cell lymphoma (DLBCL) has some shortcomings, especially for relapsed and refractory DLBCL. CD47 is now considered as a prominent target in cancer therapies, and CD47 blockade mainly inhibits the CD47-SIRPα axis to prevent tumor immune escape. Here, we evaluated the effects of the latest CD47 antibodies reported and the correlations of closely related genes with CD47 in this disease. In the future, therapeutic strategies for DLBCL will focus on multitarget antibody combined treatment and multigene joint attacks.
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