Impaired incretin homeostasis in non-diabetic moderate-severe CKD.

ABSTRACT:

Background

Incretins are regulators of insulin secretion and glucose homeostasis that are metabolized by dipeptidyl peptidase-4 (DPP-4). Moderate-severe CKD may modify incretin release, metabolism, or response.

Methods

We performed 2-hour oral glucose tolerance testing (OGTT) in 59 people with non-diabetic CKD (eGFR<60 ml/min per 1.73 m²) and 39 matched controls. We measured total (tAUC) and incremental (iAUC) area under the curve of plasma total glucagon-like peptide-1 (GLP-1) and total glucose-dependent insulinotropic polypeptide (GIP). Fasting DPP-4 levels and activity were measured. Linear regression was used to adjust for demographic, body composition, and lifestyle factors.

Results

Mean eGFR was 38 ±13 and 89 ±17ml/min per 1.73 m² in CKD an

SUBMITTER: Ahmadi A 

PROVIDER: S-EPMC10775324 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature