Lysine-36 of Drosophila histone H3.3 supports adult longevity.

ABSTRACT: Aging is a multifactorial process that disturbs homeostasis, increases disease susceptibility, and ultimately results in death. Although the definitive set of molecular mechanisms responsible for aging remain to be discovered, epigenetic change over time is proving to be a promising piece of the puzzle. Several posttranslational histone modifications (PTMs) have been linked to the maintenance of longevity. Here, we focus on lysine-36 of the replication-independent histone protein, H3.3 (H3.3K36). To interrogate the role of this residue in Drosophila developmental gene regulation, we generated a lysine to arginine mutant that blocks the activity of its cognate modifying enzymes. We found that an H3.3B^K36R mutation causes a significant reduction in adult lifes

SUBMITTER: Brown JC 

PROVIDER: S-EPMC10775331 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature