GZMK+CD8+ T cells Target A Specific Acinar Cell Type in Sjogren's Disease.

ABSTRACT: Sjögren's Disease (SjD) is a systemic autoimmune disease without a clear etiology or effective therapy. Utilizing unbiased single-cell and spatial transcriptomics to analyze human minor salivary glands in health and disease we developed a comprehensive understanding of the cellular landscape of healthy salivary glands and how that landscape changes in SjD patients. We identified novel seromucous acinar cell types and identified a population of PRR4+CST3+WFDC2- seromucous acinar cells that are particularly targeted in SjD. Notably, GZMK+CD8 T cells, enriched in SjD, exhibited a cytotoxic phenotype and were physically associated with immune-engaged epithelial cells in disease. These findings shed light on the immune response's impact on transitioning acinar cells with high leve

SUBMITTER: Pranzatelli TJF 

PROVIDER: S-EPMC10775371 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature