Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature.

ABSTRACT: The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells. SASP factors induce tissue remodeling and immune cell recruitment. Previous studies have focused on the beneficial role of SASP during embryonic development, wound healing, tissue healing in general, immunoregulation properties, and cancer. However, some recent studies have identified several negative effects of SASP on fracture healing. Senolytics is a drug that selectively eliminates senescent cells. Senolytics can inhibit the function of senescent cells and SASP, which has been found to have positive effects on a variety of aging-related diseases. At the same time, recent data suggest that remov

SUBMITTER: Zhao S 

PROVIDER: S-EPMC10775505 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature