Immune characteristics and clinical significance of peripheral blood lymphocytes in breast cancer.

ABSTRACT:

Background

In the context of breast cancer (BC), the correlation between lymphocytes and clinical outcomes, along with treatment response, has garnered attention. Despite this, few investigations have delved into the interplay among distinct peripheral blood lymphocyte (PBL) types, immune attributes, and their clinical implications within the BC landscape.

Methods

The primary objective of this study was to scrutinize the baseline status of PBL subsets in patients with primary BC, track their dynamic changes throughout treatment, and ascertain their interrelation with prognosis. Flow cytometry was employed to analyse PBLs from a cohort of 74 BC patients.

Results

Our analysis revealed that baseline levels of Treg and PD-L1 + T cells were lower in BC patients compared to

SUBMITTER: Gao H 

PROVIDER: S-EPMC10775541 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature