Synthesis, antileishmanial, antimalarial evaluation and molecular docking study of some hydrazine-coupled pyrazole derivatives.

ABSTRACT: Pyrazole-bearing compounds are known for their diverse pharmacological effects including potent antileishmanial and antimalarial activities. Herein, some hydrazine-coupled pyrazoles were successfully synthesized and their structures were verified by employing elemental microanalysis, FTIR, and ¹H NMR techniques. The in vitro antileishmanial and in vivo antimalarial activities of the synthesized pyrazole derivatives (9-15) were evaluated against Leishmania aethiopica clinical isolate and Plasmodium berghei infected mice, respectively. The result revealed that compound 13 displayed superior antipromastigote activity (IC₅₀ = 0.018) that was 174- and 2.6-fold more active than the standard drugs miltefosine (IC₅₀ = 3.130) and amphotericin B deoxycholate (IC

SUBMITTER: Berhe HG 

PROVIDER: S-EPMC10775556 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature