The synergism of cytosolic acidosis and reduced NAD⁺/NADH ratio is responsible for lactic acidosis-induced vascular smooth muscle cell impairment in sepsis.

ABSTRACT:

Background

During sepsis, serve vascular dysfunctions lead to life-threatening multiple organ failure, due to vascular smooth muscle cells (VSMC) impairments, resulting in vasoplegia, hypotension and hypoperfusion. In addition, septic patients have an altered cell metabolism that leads to lactic acidosis. Septic patients suffering from lactic acidosis have a high risk of mortality. In addition, septic survivors are at risk of secondary vascular disease. The underlying mechanisms of whether and how lactic acidosis leads to the changes in VSMCs is not well understood. The aim of this study was to comprehensively investigate the effect of lactic acidosis on VSMCs and additionally compare the effects with those induced by pure acidosis and sodium lactate.

Methods

Primary human a

SUBMITTER: Terpe P 

PROVIDER: S-EPMC10775599 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature