Ventral tegmental area dopaminergic circuits participates in stress-induced chronic postsurgical pain in male mice.

ABSTRACT:

Background

Chronic postsurgical pain (CPP) markedly impairs patients' quality of life. Research has shown that chronic stress may extend incisional nociception in male mice. Dopaminergic (DAergic) neurons in the ventral tegmental area (VTA) are integral to stress-related mental disorders (including major depressive disorder, anxiety disorders, and PTSD) and pain. However, the impact of chronic social defeat stress (CSDS) on mesolimbic dopamine (DA) transmission in the development of CPP is yet to be established. It remains uncertain whether the dopamine signals in the rostral anterior cingulate cortex (rACC), which regulate pain, derive from the VTA. This study aims to explore the role of VTA-rACC dopaminergic circuits in a mouse model of CPP induced by CSDS.

Methods

We cond

SUBMITTER: Liu W 

PROVIDER: S-EPMC10775611 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature