MiR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's dementia (AD) pathogenesis involves complex mechanisms, including microRNA (miRNA) dysregulation. Integrative network and machine learning analysis of miRNA can provide insights into AD pathology and prognostic/diagnostic biomarkers.

Methods

We performed co-expression network analysis to identify network modules associated with AD, its neuropathology markers, and cognition using brain tissue miRNA profiles from the Religious Orders Study and Rush Memory and Aging Project (ROS/MAP) (N = 702) as a discovery dataset. We performed association analysis of hub miRNAs with AD, its neuropathology markers, and cognition. After selecting target genes of the hub miRNAs, we performed association analysis of the hub miRNAs with their target genes and then performed

SUBMITTER: Han SW 

PROVIDER: S-EPMC10775662 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature