Pleural fluid carbohydrate antigen 72-4 and malignant pleural effusion: a diagnostic test accuracy study.

ABSTRACT:

Background

The prognosis of malignant pleural effusion (MPE) is poor. A timely and accurate diagnosis is the prerequisite for managing MPE patients. Carbohydrate antigen 72-4 (CA72-4) is a diagnostic tool for MPE.

Objective

We aimed to evaluate the diagnostic accuracy of pleural fluid CA72-4 for MPE.

Design

A prospective, preregistered, and double-blind diagnostic test accuracy study.

Methods

We prospectively enrolled participants with undiagnosed pleural effusions from two centers in China (Hohhot and Changshu). CA72-4 concentration in pleural fluid was measured by electrochemiluminescence. Its diagnostic accuracy for MPE was evaluated by a receiver operating characteristic (ROC) curve. The net benefit of CA72-4 was determined by a decision curve analysis (DCA

SUBMITTER: Cao XS 

PROVIDER: S-EPMC10775747 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature