Subjective cognitive complaints are important in PD-MCI criteria: Associations with CSF markers and cognitive decline.

ABSTRACT:

Introduction

According to the Movement Disorder Society (MDS), subjective cognitive complaints (SCC) are a diagnostic criterion for PD-mild cognitive impairment (PD-MCI); however, studies often do not incorporate SCC when classifying PD-MCI. This inconsistent use may reflect mixed findings regarding the association between SCC and objective measures of cognitive impairment. Our study aimed to describe the extent that inclusion/exclusion of SCC affects the occurrence of PD-MCI, and if the inclusion of SCC is associated with faster cognitive decline and cerebrospinal fluid markers (CSF) of alpha-synuclein, amyloid beta, total tau, and phophorylated-tau.

Methods

Individuals with PD (N = 358) from the PPMI cohort whom completed measures of neuropsychological performance, subject

SUBMITTER: Jones JD 

PROVIDER: S-EPMC10775883 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature