Association between gut microbiome-related metabolites and symptomatic hand osteoarthritis in two independent cohorts.

ABSTRACT:

Background

Since gut microbiome dysbiosis can cause inflammatory disorders by affecting host metabolism, we postulate that the gut microbiome and related metabolites could play a role in hand osteoarthritis. We characterised gut microbiome-related metabolites in people with symptomatic hand osteoarthritis (SHOA) in two independent cohorts.

Methods

Using data collected from a large-sample community-based observational study (discovery cohort), we assessed the relations of the microbial function and plasma key metabolites related to altered microbial function with SHOA. Finally, we verified the relations of plasma metabolites to SHOA in an independent observational study (validation cohort).

Findings

In the discovery cohort (n = 1359), compared to those without SHOA, pa

SUBMITTER: Wei J 

PROVIDER: S-EPMC10775900 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature