Estimating neuronal firing density: A quantitative analysis of firing rate map algorithms.

ABSTRACT: The analysis of neurons that exhibit receptive fields dependent on an organism's spatial location, such as grid, place or boundary cells typically begins by mapping their activity in space using firing rate maps. However, mapping approaches are varied and depend on multiple tuning parameters that are usually chosen qualitatively by the experimenter and thus vary significantly across studies. Small changes in parameters such as these can impact results significantly, yet, to date a quantitative investigation of firing rate maps has not been attempted. Using simulated datasets, we examined how tuning parameters, recording duration and firing field size affect the accuracy of spatial maps generated using the most widely used approaches. For each approach we found a clear subset of parameters

SUBMITTER: Grieves RM 

PROVIDER: S-EPMC10775984 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature