Redundant microtubule crosslinkers prevent meiotic spindle bending to ensure diploid offspring in C. elegans.

ABSTRACT: Oocyte meiotic spindles mediate the expulsion of ¾ of the genome into polar bodies to generate diploid zygotes in nearly all animal species. Failures in this process result in aneuploid or polyploid offspring that are typically inviable. Accurate meiotic chromosome segregation and polar body extrusion require the spindle to elongate while maintaining its structural integrity. Previous studies have implicated three hypothetical activities during this process, including microtubule crosslinking, microtubule sliding and microtubule polymerization. However, how these activities regulate spindle rigidity and elongation as well as the exact proteins involved in the activities remain unclear. We discovered that C. elegans meiotic anaphase spindle integrity is maintained through redundant microtub

SUBMITTER: Li W 

PROVIDER: S-EPMC10775986 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature