Adaptive immune cells are necessary for SARS-CoV-2-induced pathology.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the ongoing global pandemic associated with morbidity and mortality in humans. Although disease severity correlates with immune dysregulation, the cellular mechanisms of inflammation and pathogenesis of COVID-19 remain relatively poorly understood. Here, we used mouse-adapted SARS-CoV-2 strain MA10 to investigate the role of adaptive immune cells in disease. We found that while infected wild-type mice lost ~10% weight by 3 to 4 days postinfection, rag^-/- mice lacking B and T lymphocytes did not lose weight. Infected lungs at peak weight loss revealed lower pathology scores, fewer neutrophils, and lower interleukin-6 and tumor necrosis factor-α in rag^-/- mice. Mice lacking αβ T cells

SUBMITTER: Imbiakha B 

PROVIDER: S-EPMC10775995 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature