Advances in heavy alkaline earth chemistry provide insight into complexation of weakly polarizing Ra²⁺, Ba²⁺, and Sr²⁺ cations.

ABSTRACT: Numerous technologies-with catalytic, therapeutic, and diagnostic applications-would benefit from improved chelation strategies for heavy alkaline earth elements: Ra²⁺, Ba²⁺, and Sr²⁺. Unfortunately, chelating these metals is challenging because of their large size and weak polarizing power. We found 18-crown-6-tetracarboxylic acid (H₄COCO) bound Ra²⁺, Ba²⁺, and Sr²⁺ to form M(H_xCOCO)^x-2. Upon isolating radioactive ²²³Ra from its parent radionuclides (²²⁷Ac and ²²⁷Th), ²²³Ra²⁺ reacted with the fully deprotonated COCO^4- chelator to generate Ra(COCO)<

SUBMITTER: Gilhula JC 

PROVIDER: S-EPMC10776001 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature