Rehabilitation exercise-driven symbiotic electrical stimulation system accelerating bone regeneration.

ABSTRACT: Electrical stimulation can effectively accelerate bone healing. However, the substantial size and weight of electrical stimulation devices result in reduced patient benefits and compliance. It remains a challenge to establish a flexible and lightweight implantable microelectronic stimulator for bone regeneration. Here, we use self-powered technology to develop an electric pulse stimulator without circuits and batteries, which removes the problems of weight, volume, and necessary rigid packaging. The fully implantable bone defect electrical stimulation (BD-ES) system combines a hybrid tribo/piezoelectric nanogenerator to provide biphasic electric pulses in response to rehabilitation exercise with a conductive bioactive hydrogel. BD-ES can enhance multiple osteogenesis-related biological pro

SUBMITTER: Wang T 

PROVIDER: S-EPMC10776020 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature