The chemokine receptor CXCR3 promotes CD8⁺ T cell-dependent lung pathology during influenza pathogenesis.

ABSTRACT: The dual role of CD8⁺ T cells in influenza control and lung pathology is increasingly appreciated. To explore whether protective and pathological functions can be linked to specific subsets, we dissected CD8⁺ T responses in influenza-infected murine lungs. Our single-cell RNA-sequencing (scRNA-seq) analysis revealed notable diversity in CD8⁺ T subpopulations during peak viral load and infection-resolved state. While enrichment of a Cxcr3^hi CD8⁺ T effector subset was associated with a more robust cytotoxic response, both CD8⁺ T effector and central memory exhibited equally potent effector potential. The scRNA-seq analysis identified unique regulons regulating the cytotoxic response in CD8⁺ T cells. The late-stage C

SUBMITTER: Guo K 

PROVIDER: S-EPMC10776024 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature