Adaptive advantages of restorative RNA editing in fungi for resolving survival-reproduction trade-offs.

ABSTRACT: RNA editing in various organisms commonly restores RNA sequences to their ancestral state, but its adaptive advantages are debated. In fungi, restorative editing corrects premature stop codons in pseudogenes specifically during sexual reproduction. We characterized 71 pseudogenes and their restorative editing in Fusarium graminearum, demonstrating that restorative editing of 16 pseudogenes is crucial for germ tissue development in fruiting bodies. Our results also revealed that the emergence of premature stop codons is facilitated by restorative editing and that premature stop codons corrected by restorative editing are selectively favored over ancestral amino acid codons. Furthermore, we found that ancestral versions of pseudogenes have antagonistic effects on reproduction and surv

SUBMITTER: Qi Z 

PROVIDER: S-EPMC10776026 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature