Enhancing Neuroplasticity in the Chronic Phase After Stroke: Effects of a Soft Robotic Exosuit on Training Intensity and Brain-Derived Neurotrophic Factor.

ABSTRACT: Objective: High intensity training may enhance neuroplasticity after stroke; however, gait deficits limit the ability to achieve and sustain high walking training intensities. We hypothesize that soft robotic exosuits can facilitate speed-based gait training at higher intensities and longer durations, resulting in a corresponding increase in circulating brain-derived neurotrophic factor (BDNF). Results: Eleven individuals >6-mo post-stroke completed a two-session, pilot randomized crossover trial (NCT05138016). Maximum training speed (Δ: 0.07 ± 0.03 m/s), duration (Δ: 2.07 ± 0.88 min), and intensity (VO₂ peak, Δ: 1.75 ± 0.60 ml-O₂/kg/min) significantly increased (p < 0.05) during exosuit-augmented training compared to no-exosuit training. Post-session in

SUBMITTER: Cataldo AVR 

PROVIDER: S-EPMC10776098 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature