Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy.

ABSTRACT: Aging is a major risk factor for most chronic disorders, for which cellular senescence is one of the central hallmarks. Senescent cells develop the pro-inflammatory senescence-associated secretory phenotype (SASP), which significantly contributes to organismal aging and age-related disorders. Development of senotherapeutics, an emerging class of therapeutic agents to target senescent cells, allows to effectively delay aging and alleviate chronic pathologies. Here we report preliminary outputs from screening of a natural medicinal agent (NMA) library for senotherapeutic candidates and validated several agents with prominent potential as senomorphics. Rutin, a phytochemical constituent found in a number of plants, showed remarkable capacity in targeting senescent cells by dampening expressio

SUBMITTER: Liu H 

PROVIDER: S-EPMC10776113 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature