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Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity.

ABSTRACT: Somatic mutations accumulate with age and are associated closely with human health, their characterization in longevity cohorts remains largely unknown. Here, by analyzing whole genome somatic mutation profiles in 73 centenarians and 51 younger controls in China, we found that centenarian genomes are characterized by a markedly skewed distribution of somatic mutations, with many genomic regions being specifically conserved but displaying a high function potential. This, together with the observed more efficient DNA repair ability in the long-lived individuals, supports the existence of key genomic regions for human survival during aging, with their integrity being of essential to human longevity.

SUBMITTER: Wang HT

PROVIDER: S-EPMC10776117 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity.

Wang Hao-Tian HT Zhao Long L Yang Li-Qin LQ Ge Ming-Xia MX Yang Xing-Li XL Gao Zong-Liang ZL Cun Yu-Peng YP Xiao Fu-Hui FH Kong Qing-Peng QP

Aging cell 20230703 1

Somatic mutations accumulate with age and are associated closely with human health, their characterization in longevity cohorts remains largely unknown. Here, by analyzing whole genome somatic mutation profiles in 73 centenarians and 51 younger controls in China, we found that centenarian genomes are characterized by a markedly skewed distribution of somatic mutations, with many genomic regions being specifically conserved but displaying a high function potential. This, together with the observe ...[more]

PMID: 37400997

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